We identified six genes, including NCOA1, ANKRD36BP2, PAPD4, PRRC2C, SCLT1 and EIF2AK1, producing circRNA isoforms with opposite expression patterns, and characterized some inflammation-related circRNAs, such as chr9:15474007-15490122, chr16:75445723-75448593, hsa_circ_0007256, chr12:56563313-56563992, and hsa_circ_0003533, which may be associated with inflammatory responses in AF. This evidence concerns the gene PRRC2C and atrial fibrillation.