MARK2 and neoplasm: Cyclin-dependent kinase 1 (CDK1) is a protein that regulates the cell cycle, which belongs to a serine/threonine kinase family (Malumbres and Barbacid, 2009); previous studies have proved that CDK1 acted as a key regulator for cell cycle (Yang et al., 2016), and its expression increases in several cancer growths, such as colon carcinoma (Meyer et al., 2009), non-small cell lung cancer tumor (Kim et al., 2008; Zhang et al., 2011); There are also researches that identify that inhibition of CDK1 can suppress the proliferation and migration of some tumor cells (Zhang et al., 2015).