CAST and obesity due to melanocortin 4 receptor deficiency: Modulation of other inflammation-related pathways, such as the NFAT signaling cascade, known to be involved in inflammasome activation and in the regulation of adipokine transcription in AT of animal models (59, 60), and the CAPN10/CAST system, known to influence multiple functions including apoptosis, fibrosis and inflammation (61), and the FYN gene, shown to be an important regulator of inflammatory signaling in AT (62), was also observed in obesity and obesity-associated CRC conditions.