The biological processes “Platelet degranulation,” “Positive regulation of glucose import” and “Cellular response to insulin stimulus,” already found modulated in obesity (PDGFB, SERPING1 ADIPOQ, PIK3R1, IGF1) were further enriched in ObCRC with respect to Ob individuals. This evidence concerns the gene PIK3R1 and obesity due to melanocortin 4 receptor deficiency.