In this context it is of interest that among genes deregulated under CRC conditions, the majority are involved in cell adhesion/migration processes and ECM remodeling, such as collagens (e.g., COL4A2, COL6A3), or genes encoding for structural and non-structural matricellular proteins (e.g., ECM2, SPARC and DDR1). This evidence concerns the gene SPARC and colorectal carcinoma.