BAFF has also been reported to have a different functional role in experimental autoimmune encephalomyelitis (EAE); specifically, BAFFR gene-deficient mice show increased peripheral inflammatory cytokines and higher disease severity compared with wild-type animals, suggesting alteration of macrophage activation and immune responses in the absence of BAFFR (40). The gene discussed is TNFRSF13C; the disease is experimental autoimmune encephalomyelitis.