In a recent (2018) review of all published LAD cases before 2017 (323 cases) (100) it was reported that the most common infections in severe LAD-I (<2% CD18 expression) were respiratory tract infections (including pneumonia), sepsis, and otitis media whilst in LAD-I with moderate CD18 expression the most common infections were periodontal infection, otitis media and sepsis. Here, ITGB2 is linked to otitis media.