Adoptive transfer of antigen-specific Treg, either expanded from natural occurring Treg, or induced from conventional T cells, e.g., by enforcing the expression of the Treg-specific transcription factor FoxP3 or reprogramming through tolDCs, has been shown to suppress the progression of arthritis in models of CIA, PGIA and AIA (125–129). This evidence concerns the gene FOXP3 and arthritic joint disease.