MITF and coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness: MITF deficiency is responsible for COMMAD (coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness) syndrome in two unrelated patients, suggesting a role for MITF in regulating various processes beside bone development and homeostasis (43).