SNCA and Parkinson disease: This interplay seems to underlie neuroinflammation which, apart from PD, is a constant feature of numerous neurodegenerative diseases such as Alzheimer's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, frontotemporal dementia or Huntington's disease (6) and may have multiple causes, including deficient regulation of immune responses associated with age advancement, infectious agents (bacteria or viruses), exotoxins (e.g., pesticides or MPTP), or deposition of insoluble protein fibrils (e.g., alpha-synuclein).