In particular, it has been demonstrated that in the absence of Hh signaling the interaction of β-arr2 with the E3 ligase Itch and Suppressor of Fused (SuFu), a tumour suppressor gene, promotes the processing of Gli3 transcription factor into a cleaved repressor form, GLI3R, unveiling a new role of β-arr2 in controlling the immunosuppressive function of SuFu and maintaining the signaling off in the absence of ligand (Infante et al., 2018). The gene discussed is SUFU; the disease is neoplasm.