HIF1A and neoplasm: Concordantly, in ovarian cancer, the activation of ET-1R, by mimicking hypoxia, promotes the interaction between β-arr1/p300 and HIF-1α, enhancing the transcription of genes, such as ET-1 and VEGF, required for tumor cell invasion and proangiogenic effects, operating a self-amplifying HIF-1α-mediated transcription of genes that sustain metastatic process (Cianfrocca et al., 2016).