ARRB2 and hepatocellular carcinoma: Previous studies demonstrated that β-arr2 depletion promoted tumor growth and angiogenesis in a murine model of lung cancer (Raghuwanshi et al., 2008) and that low expression of β-arr2 is significantly associated with aggressive pathologic features and is predictive of poor patient prognosis, as observed in lung and hepatocellular carcinoma (Sun et al., 2016; Cong et al., 2017).