In myeloid leukemia where β-arr mediates the initiation and maintenance of tumor cells (Fereshteh et al., 2012; Kotula et al., 2014), the interaction of β-arr1 with the DNA-binding Enhancer of Zeste Homologue 2 (EZH2) protein mediates BCR/ABL histone acetylation during tumor progression (Qin et al., 2014). The gene discussed is EZH2; the disease is neoplasm.