In Sonic Hedgehog medulloblastoma, where aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of tumor initiation and progression, β-arr1 promotes p300-mediated acetylation of Gli1 inhibiting its function, acting as negative regulators of self-renewal (Miele et al., 2017). The gene discussed is GLI1; the disease is neoplasm.