ARRB2 and hereditary clear cell renal cell carcinoma: By contrast, other results are consistent with the idea that β-arr2 action provides a supportive role in the development of human tumors, and β-arr2 is overexpressed in different human tumors, including breast and renal cell carcinoma, correlating with advanced stage and decreased patient survival, and mediates different tumor-promoting effects, such as cell migration and invasion (Sun et al., 2002; Ge et al., 2004; Alemayehu et al., 2013; Masannat et al., 2018).