GRK2 and metabolic dysfunction-associated steatohepatitis: In keeping with these results, our group has shown that GRK2 levels were increased in the liver of mice fed a HFD (Garcia-Guerra et al., 2010) or a methionine and choline-deficient diet (MCD), as a mouse model of NASH, and also in human patients diagnosed with NASH (Cruces-Sande et al., 2018).