GRK2 and Sepsis: For instance, a reduction of GRK2 in myeloid cells increases the risk of septic shock in mouse models (Patial et al., 2011), although myeloid-specific GRK2 does not alter immune cell infiltration to the primary site of infection or bacterial clearance and does not significantly affect mortality in a cecal ligation puncture model of polymicrobial sepsis (Parvataneni et al., 2011).