Also supporting a key role for GRK2 in insulin/GPCR pathways crosstalk, hyperinsulinemia associated to type 2-diabetes fosters β2AR phosphorylation leading to decreased βAR-regulated cardiac contractility, in a manner dependent on IRS1/IRS2, PKA, and GRK2 activity (Fu et al., 2014), this effect being potentiated upon GRK2 over expression and prevented upon GRK2 inhibition (Wang et al., 2017a). Here, GRK2 is linked to type 2 diabetes mellitus.