GRK2 and heart failure: On the other hand, adenoviral-mediated delivery of the C-terminal region of GRK2 (βARKct) also has a protective effect in heart failure and acute myocardial infarction settings in murine and pig models (reviewed in Sato et al., 2015b; Cannavo and Koch, 2018; de Lucia et al., 2018) by mechanisms likely involving prevention of the activation of GRK2 by Gβγ subunits (Rudomanova and Blaxall, 2017b).