Moreover, GRK2 deletion 10 days after myocardial infarction (Raake et al., 2008) or treatment with the GRK2 inhibitor paroxetine (see below) started 2 weeks after injury (Schumacher et al., 2015) improves cardiac function and reduces adverse ischemic remodeling in mice. The gene discussed is GRK2; the disease is myocardial infarction.