GRK2 and hypertensive disorder: This apparently preferential desensitization by GRK2 of vasodilation versus vasoconstriction signaling has been invoked to explain the effect of upregulated GRK2 levels seen in human and murine hypertension (Eckhart et al., 2002; Izzo et al., 2008; Cohn et al., 2009; Santulli et al., 2013).