On the other hand, transverse aortic constriction and continued angiotensin II-mediated stimulation of Gq-coupled AT1 receptors cause increased GRK2 expression in the context of cardiac hypertrophy, and GRK2 has also been shown to modulate angiotensin II-mediated contraction by directly interacting with Gαq (Schumacher et al., 2016). Here, AGT is linked to cardiac hypertrophy.