On the other hand, adenoviral-mediated delivery of the C-terminal region of GRK2 (βARKct) also has a protective effect in heart failure and acute myocardial infarction settings in murine and pig models (reviewed in Sato et al., 2015b; Cannavo and Koch, 2018; de Lucia et al., 2018) by mechanisms likely involving prevention of the activation of GRK2 by Gβγ subunits (Rudomanova and Blaxall, 2017b). This evidence concerns the gene GRK2 and acute myocardial infarction.