Only, one paper has been published analyzing alterations in the expression of GRK2 and ARs in atrial myocytes of patients with congenital heart disease operated on with cardiopulmonary bypass (Oliveira et al., 2017) but, in this case, the alterations were related to the vulnerability of the myocardium to catecholamine levels in an acute surgical context. The gene discussed is GRK2; the disease is congenital heart disease.