In the current study, we investigated 16 SNPs in the 5′-untranslated region (5′-UTR) and coding regions of the ADRB2 gene, including several SNPs that have not been studied for pain (e.g., 5′-UTR rs1042711), on their influence on acute and chronic pain in patients with SCD. Here, ADRB2 is linked to Schnyder corneal dystrophy.