Among S-allele carries, in comparison to MDD patients, there was a significantly higher rate of BP patients with PM in either CYP2D6 or CYP2C19. There was no significant difference in distribution of treatment guided recommendations groups between SLC6A4 phenotypes [l/l (GGR = 31.9%, TAU = 26.8%), s/l (GGR = 47.2%, TAU = 32.1%), and s/s (GGR = 20.9%, TAU = 15.9%) (p = 0.13)] (Table 3). This evidence concerns the gene CYP2D6 and major depressive disorder.