HTR5A and Coma: However, LPM580098 does not induce sedation and somnolence, which may be largely attributed to the presynaptic reuptake inhibition of DA, and partly 5-HT and NE reuptake inhibition in brain regions associated with sleep–wake cycle, considering that the NE and 5-HT reuptake inhibitor duloxetine produces significant sedation and somnolence.