VEGFA and neoplasm: Inflammation plays an important role in tumor angiogenesis, which is mainly manifested through the activation of NF-κB to regulate VEGF, and results have shown that berberine treatment of tumor cells significantly inhibited NF-κB and ultimately decreased the expression of VEGF and IL-8 in tumor cells (Hamsa and Kuttan, 2011; Siveen and Kuttan, 2011).