MAPT and Alzheimer disease: It has been reported that mild and moderate stress conditions increase the level of amyloid precursor protein (APP), generation of Aβ peptide, intracellular NFTs, intracellular hyperphosphorylated tau, loss of synaptic plasticity, and extracellular APs that are associated with AD pathogenesis in the animals (Rothman and Mattson, 2010; Bisht et al., 2018; Justice, 2018; Figure 2).