Strikingly, TDP-43 has also been found to form cytoplasmic and sarcoplasmic inclusions in several other diseases such as: the Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD), sporadic IBM, myofibrillar myopathies, oculopharyngeal muscular dystrophy (OPMD) and distal myopathies with rimmed vacuoles (DMRV) (Weihl et al., 2008; Kusters et al., 2009; Olive et al., 2009; Salajegheh et al., 2009). This evidence concerns the gene TARDBP and frontotemporal dementia.