Furthermore, overexpression of the mammalian Sis1 homolog, DNAJB1, in the primary rodent neurons could also relieve the TDP-43-mediated toxicity, suggesting that Sis1 and its related homolog might have neuroprotective effects for ALS (Park et al., 2017). The gene discussed is DNAJB1; the disease is amyotrophic lateral sclerosis.