Further evidence from the works of Watanabe et al. (2013) and Austin et al. (2014), has shown that the accelerated disease onset in the familial ALS patients is related to the TDP-43 mutations (such as: A315T, Q343R, N352S, M337V, G298S, G348C, A382T, D169G, and K263E) possibly via increase in the protein half-lives and the aggregation propensities, which may further influence their own mRNA's processing and cause misregulation of the TDP-43's translation (Watanabe et al., 2013; Austin et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.