TARDBP and early-onset autosomal dominant Alzheimer disease: Notably, immunoreactivity of TDP-43 has also been detected in the Alzheimer's disease brain, in about 75% of the patients (Amador-Ortiz et al., 2007; Higashi et al., 2007; Uryu et al., 2008; King et al., 2010b; Josephs et al., 2014).