Furthermore, an ALS-linked TDP-43 M337V mutant, was shown to decrease the global expression levels of a key epigenetic marker, H3S10Ph-K14Ac in neuronal cells, whereas, the overexpression of wild-type TDP-43 caused an increase in the histone H3K9Me3 levels (Masala et al., 2018). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.