TARDBP and amyotrophic lateral sclerosis: In one study, the ALS-linked TDP-43 with the mutations G298S, Q331K, and M337V, showed longer half-life and higher stability than the wild-type TDP-43 (half-life: ~24–48 h vs. 12 h for the wild-type TDP-43) in an isogenic cell line (Ling et al., 2010).