Peptides from the TDP-43's putative amyloidogenic core region (aa 286–366) containing the ALS-associated mutations were also found to efficiently form amyloid-like fibrils (Chen et al., 2010; Guo et al., 2011; Sun et al., 2011; Zhu et al., 2014) (Table 2). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.