TARDBP and amyotrophic lateral sclerosis: Also, inhibition of the TDP-43's accumulation into stress granules and inhibition of the C-terminal fragment aggregation, were reported in the ALS models treated with copper complexes CuII(btsc) and CuII(atsm), which proposedly act by slowly releasing the CuII-ions within certain sub-cellular compartments like the stress granules (Donnelly et al., 2008; Crouch et al., 2009; Parker et al., 2012).