TARDBP and amyotrophic lateral sclerosis: Wang et al. suggest that a phosphomimetic substitution at S48 in the NTD disrupts the TDP-43's LLPS and decreases the NTD's polymerization, and thus, it is a conserved phosphorylation site found to be phosphorylated at low levels in the ALS in vivo models (Wang et al., 2018).