Additionally, levels of the functional subunits of neuronal Brg1-associated factor (nBAF), which is another chromatin remodeling protein critical for the neuronal differentiation, dendritic extension and synaptic function, was reduced by mutant TDP-43 in the cultured motor neurons and in the ALS spinal motor neurons (Tibshirani et al., 2017). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.