TARDBP and early-onset autosomal dominant Alzheimer disease: In another study, Herman et al., using mice Alzheimer's disease models, have found that the Aβ-42 amyloid can trigger the TDP-43 pathology, thus, the TDP-43 and Aβ-42 oligomers/aggregates appear to be capable of cross-seeding each other into toxic species (Herman et al., 2011; Fang et al., 2014; Chang et al., 2016).