TARDBP and amyotrophic lateral sclerosis: Additionally, Smethurst et al. have identified a diverse range of TDP-43 inclusion bodies, such as skeins, dot-like, and granular etc., upon seeding with the pathological TDP-43 aggregates from different ALS patient's brains into the cells expressing full-length TDP-43, possibly indicating strain-like propagation characteristic of prions.