TARDBP and amyotrophic lateral sclerosis: However, in certain other studies, both wild-type and ALS-associated mutant TDP-43's peptides have been shown to efficiently form β-sheet-rich, ThT-positive fibrillar aggregates suggestive of their amyloid-like nature (Chen et al., 2010; Guo et al., 2011; Sun et al., 2011; Zhu et al., 2014) (Table 2).