TARDBP and neurodegenerative disease: Strikingly, out of nearly 240 human proteins that harbor a potential prion-like domain, about 70 of them are RNA/DNA-binding proteins containing an RRM motif, several of which, including TDP-43, FUS, hnRNPs, TATA-box binding protein associated factor 15 (TAF15), and EWS RNA binding protein 1 (EWRS1) etc., are being implicated in the pathogenesis of various neurodegenerative diseases (March et al., 2016; Harrison and Shorter, 2017).