SLC6A3 and Cognitive impairment: Another DAT preferring stimulant, 3,4-methylenedioxypyrovalerone, produces CPP at much lower dose than amphetamine in C57Bl/6 mice (Simmler et al., 2013; Karlsson et al., 2014) and produces cognitive deficits upon repeated exposure in rats (Sewalia et al., 2018).