PLD3 and Alzheimer disease: Considering their probably deleterious effects on PLD3 functions based on Polyphen-2 and SIFT scores (Tan et al., 2018), and the evidence that variants in PLD3 were associated with amyloid pathology and cognitive decline (Wang et al., 2015, 2016; Lin et al., 2017; Engelman et al., 2018), we need to assess the functional consequence of these variants and investigate the possible mechanisms by which they influence AD pathogenesis.