IDE and Alzheimer disease: In support of this observation, a transgenic mouse model of AD [harboring the Swedish (K670N/M671L) and Indiana (V717F) APP mutations] placed on a diet enriched with high oleic acid levels showed neuroprotective effects typified by reduced BACE, increased amyloid clearance enzyme (IDE) and reduced amyloid plaques (Amtul et al., 2011).