Hepcidin mRNA levels increased early in the brain in response to ischemia in a model of endothelin-induced vasoconstriction (Bickford et al., 2014), and hepcidin levels were significantly elevated in the ischemic side of the brain 24 h after occlusion in a stroke model due to middle cerebral artery occlusion; this ischemic side also showed increased TfR1 and FT levels and reduced FPN levels (Ding et al., 2011). The gene discussed is HAMP; the disease is stroke disorder.