The miRSystem predicted that hsa-miR-143 (the hub detected by ST5 and ST6), has-miR-145, and hsa-miR-363 (the hub detected by twocor) are connected to pathways related to lung cancer, such as GNRH signaling pathway18 (empirical-p-value is 0.01490), calcium signaling pathway19 (empirical-p-value is 0.01872), and TGF-BETA signaling pathway20 (empirical-p-value is 0.02706). Here, GNRH1 is linked to lung cancer.