HDAC5 and central nervous system cancer: HDAC5 is constitutively upregulated in U87MG, and in U251MG, T98G, and LN-229 glioma cell lines; HDAC5 promotes their proliferation by upregulation of Notch 1, whereas the knockdown of HDAC5 by siRNA suppressed proliferation and induced apoptosis in these glioma cell lines28,45.