HDAC5 is constitutively upregulated in U87MG, and in U251MG, T98G, and LN-229 glioma cell lines; HDAC5 promotes their proliferation by upregulation of Notch 1, whereas the knockdown of HDAC5 by siRNA suppressed proliferation and induced apoptosis in these glioma cell lines28,45. Here, NOTCH1 is linked to central nervous system cancer.