MELK and glioblastoma: Consistently, the expression levels of cell cycle associated genes (such as CCNE1, CDK2, CDK6, and CDC25C) and GBM enriched genes (such as TPX2, RRM2, MELK, and TNC), which were highly expressed in GBM cells than normal astrocytes33, were downregulated by FTT (Fig. 3E).