Tranilast and Fasudil were inhibitors for TGF-β and Rho kinase, and the effects of Tranilast or Fasudil could be mimicked by some other inhibitors for TGF-β or Rho kinase, suggesting that inhibition of TGF-β and Rho kinase contributed to the neuronal reprogramming of GBM cells. The gene discussed is TGFB1; the disease is glioblastoma.