SETX and mild neurocognitive disorder: Interestingly, when Chmp7 expression was examined in the spinal cord of presymptomatic mice from two separate mouse models of MND, the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) and the SETX-R2136H model of ALS4, an adolescent-onset form of ALS, we found no significant differences between WT and mutant mice (Supplementary Information, Fig. S5).