The resulting PPI network (Fig. 1G) centred on EGFR (epidermal growth factor receptor, a receptor tyrosine kinase of the ErbB family), UQCRC1 (ubiquinol-cytochrome c reductase core protein I, part of the mitochondrial respiratory chain), FANCE (Fanconi anemia complementation group E, functions in DNA repair) and CTNNB1 (catenin (cadherin-associated protein) beta 1), a downstream component of the canonical WNT signalling pathway. Here, CTNNB1 is linked to Fanconi anemia.