Furthermore, proteins/genes were enriched in several KEGG Pathways including: Huntington’s disease, Alzheimer’s disease, Parkinson’s disease, ErbB signalling pathway, adherens junction, WNT signalling pathway, focal adhesion, tight junction, neurotrophin signalling pathway, insulin signalling pathway and endocytosis (Table 1). Here, BDNF is linked to early-onset autosomal dominant Alzheimer disease.