CHMP7 and Kennedy disease: In addition, when we examined the expression of CHMP7 in a human SBMA cell model generated from iPSC derived pMNs generated from SBMA patients, we found a significant decrease in two of the three SBMA lines studied (SB3, 1.47 fold decrease, **P < 0.01; SB5, 1.32 fold decrease, **P < 0.01), compared to the two unaffected control lines (Fig. 2F).