GIMAP4 and neoplasm: In contrast, genes related to the regulation of cell death were down modulated: cell death specification protein 2, with a direct link to the activation of apoptosis58; protocadherin Fat 1, a tumor suppressor and inhibitor of cell migration59; and GTPase IMAP family member 4, member of the GIMAP family which may play a role in defense cells differentiation and apoptosis60,61.