Analyzing the GSEA data, we found that in prostate cancer the CHANDRAN_METASTASIS_UP (listed in Supplementary Table 2) gene set and a predefined HIF-1 and HIF-2 gene set PID_HIF1_AND_HIF2_PATHWAY (listed in Supplementary Table 3) were significantly enriched in the Low_FGFR2 group (Fig. 1c). This evidence concerns the gene HIF1A and Familial prostate cancer.