Indeed, ectopic expression of p47 in ATLL cell lines induced NEMO degradation and inhibition of NF-κB activation with retardation of cell growth, while the knock-down of p47 in HTLV-1-negative T-ALL cell lines induced NF-κB activation and acceleration of cell growth under TNF-α stimulation. Here, NFKB1 is linked to adult T-cell leukemia/lymphoma.