The expression levels of p47 in leukemic cells from acute-type ATLL patients were comparable or higher than those in CD4+ T lymphocytes (Fig. 4C); however, the p47 protein levels were drastically decreased with the converse up-regulation of CADM1 in leukemia cells from all ATLL patients compared with the CD4+ T lymphocytes (Fig. 4D). Here, CADM1 is linked to leukemia.