Because inhibition of the autophagy pathway efficiently decreases CADM1 expression via NF-κB signaling inactivation, a new concept that NF-κB inhibitors induce autophagy suppression may be adapted for the suppression of not only ATLL cell survival but also organ invasion with resistance to anti-cancer drugs as a valuable target for ATLL. This evidence concerns the gene NFKB1 and adult T-cell leukemia/lymphoma.