On the other hand, shRNA-mediated down-regulation of p47 in the Jurkat or MOLT4/T-ALL cell lines induced the accumulation of NEMO with a reduction of the total IκBα and enhanced phosphorylation of IκBα, resulting in the induction of CADM1 expression and acceleration of cell growth via activation of the canonical NF-κB signaling pathway under TNF-α stimulation (Figs 5C,D and S4B). This evidence concerns the gene TNF and acute lymphoblastic leukemia.