NFKB1 and adult T-cell leukemia/lymphoma: Therefore, it is speculated that the activation of the NF-κB pathway may up-regulate the autophagy-lysosome pathway in HTLV-1-infected and ATLL cells and that the enhanced degradation of p47 by targeting it to the autophagy pathway via an unknown mechanism may promote further activation of the NF-κB pathway, likely contributing to the sustained activation of autophagy.