CADM1 and adult T-cell leukemia/lymphoma: After treatment of the two HTLV-1-infected cell lines (MT2 and MT4) and two ATLL-derived cell lines (KK1 and KOB) with the proteasomal inhibitor MG132, p47 and CADM1 protein levels were not affected, although NIK levels were increased as a positive control (Fig. 6A).