Another study showed that Tax expression in the T-cell acute lymphoblastic leukemia (T-ALL) CEM cell line does not induce CADM1 expression, but it highly activates CADM1 expression in combination with the phorbol 12-myristate 13-acetate (PMA)/calcimycin (CAI) treatment through T-cell activation7. This evidence concerns the gene CNTN2 and acute lymphoblastic leukemia.