To determine whether the down-regulation of p47 expression is associated with the overexpression of CADM1 in ATLL cells, we transfected with the p47 expression vector into HTLV-1-related cell lines (HUT102 and KK1) and analyzed for the expression of CADM1 and NF-κB signaling proteins, NEMO and IκBα. This evidence concerns the gene CADM1 and adult T-cell leukemia/lymphoma.