CPS1 and coronary artery disorder: Removing the strong but pleiotropic CPS1 locus from the 6 SNP score increased the causal effect estimate of glycine on CHD risk (sex-combined: OR = 0.80 [0.71,0.91], p = 4.8 × 10−4) (Fig. 5c), and a similar effect estimate was obtained when using the 2 SNP score (GCSH and GLDC) (sex-combined: OR = 0.80 [0.69,0.92], p = 1.7 × 10−3) (Fig. 5d, Supplementary Table 2, Supplementary Figures 3 and 4).