However, when using the 5 and 2 SNP scores which excluded CPS1, the association of glycine with T2D reached significance (Sex-combined OR based on 5 SNP score = 0.85 [0.76,0.96], p = 0.007; OR based on 2 SNP score = 0.82 [0.72,0.94], p = 0.004) (Supplementary Figures 8-10, Supplementary Table 6). This evidence concerns the gene CPS1 and type 2 diabetes mellitus.