We have traditionally used these histopathological scoring criteria to grade progressive neoplastic disease in estrogen-treated HPV transgenic mice (29, –, 32), in which expression of the HPV16 oncogenes E6 and/or E7 is directed to basal cells of stratified epithelia using the keratin 14 (K14) promoter (36, 37). The gene discussed is KRT14; the disease is neoplasm.