This higher proliferation rate is accompanied by an increased expression of the stress markers, S100 calcium binding proteins A8/9 (S100A8/9) and S100 calcium binding protein A7 (S100A7), known to be highly expressed in skin cancers, suggesting that inflammasome-dependent IL-1 production may be sufficient to induce skin hyperplasia [209]. This evidence concerns the gene S100A7 and skin cancer.