Nevertheless, a compound isolated from Nigella sativa seeds, called thymoquinone (2-isopropyl-5-methyl benzo-1,4-quinone), was found to inhibit migration of melanoma cells through inhibition of NLRP3 expression and its related cascade, leading to a decrease in caspase-1 cleavage as well as IL-1 and IL-18 levels [215]. This evidence concerns the gene CASP1 and melanoma.