The sienna3 module had 25 erythroblast-specific genes, including genes involved in congenital hemolytic anemia (ANK1 (ankyrin 1), EPB42 (erythrocyte membrane protein band 4.2), HK1 (hexokinase 1), SLC4A1 (solute carrier family 4 member 1 (Diego blood group)), and SPTB (spectrin beta, erythrocytic)), hereditary spherocytosis (spherical-shaped erythrocytes) (ANK1, EPB42, SLC4A1, SPTB), anemia (ALAS2 (5′-aminolevulinate synthase 2), ANK1, EPB42, HK1, KLF1 (Kruppel like factor 1), SLC2A1, SLC4A1, SPTB), heme biosynthesis (ALAS2), and heme degradation (BLVRB, biliverdin reductase B). The gene discussed is ALAS2; the disease is anemia (phenotype).