The sienna3 module had 25 erythroblast-specific genes, including genes involved in congenital hemolytic anemia (ANK1 (ankyrin 1), EPB42 (erythrocyte membrane protein band 4.2), HK1 (hexokinase 1), SLC4A1 (solute carrier family 4 member 1 (Diego blood group)), and SPTB (spectrin beta, erythrocytic)), hereditary spherocytosis (spherical-shaped erythrocytes) (ANK1, EPB42, SLC4A1, SPTB), anemia (ALAS2 (5′-aminolevulinate synthase 2), ANK1, EPB42, HK1, KLF1 (Kruppel like factor 1), SLC2A1, SLC4A1, SPTB), heme biosynthesis (ALAS2), and heme degradation (BLVRB, biliverdin reductase B). This evidence concerns the gene SPTB and Congenital hemolytic anemia.