TP53 and systemic lupus erythematosus: The pathogenesis of lupus was found to be reacted to the following: metabolic pathways (the highest enrichment, P = 2 × 10−6), p53 signaling pathway (second highest enrichment, P = 5.25 × 10−5), and other pathways involved in FoxO signaling (P = 0.01), sphingolipid metabolism (P = 0.011), and cell adhesion molecules (CAMs) (P = 0.016) [19–21].