Hence, we speculate that TCONS_00195779-miR-92a-1-5p-IFIT1 (up-down-up), TCONS_00195779-miR-3667-3p-CXCL10 (up-down-up), and ENST00000566788.1-miR-182-5p-MALT1 (down-up-down) are a possible SLE-related lncRNA–miRNA–mRNA axis. The gene discussed is MALT1; the disease is systemic lupus erythematosus.