We also further made experiments to confirm the following: (1) the differential expression of lncRNAs may be gender-dependent in SLE patients, (2) a positive correlation between IFN-α and disease activity in SLE patients, and (3) PBMCs exhibiting differential expression of lncRNAs may be due to a change in the number of a cell type. Here, IFNA1 is linked to systemic lupus erythematosus.