It is only very recently (January 2019) that the first animal model study was published to assess the effect of exercise in DM1 (access to a running wheel for 7 weeks) by Manta et al. [47] This study demonstrates very interesting results about the effect of exercise in DM1: it improves strength and endurance, normalizes electromyographic signal (an indication of reduced myotonia), increases mitochondrial content, decreases accumulation of CUG RNA resulting in a decreased sequestration of MBNL-1 among other physiological benefits [47]. This evidence concerns the gene MBNL1 and Myotonia.