Three out of 20 genes located in the identified ROH islands were listed in OMIM (Online Mendelian Inheritance in Man) database (DGKE - 615,008~Hemolytic uremic syndrome; HOXB1–614744~Facial paresis; SPRY4–615266~Hypogonadotropic hypogonadism), but none of the identified genes were listed in OMIA (Online Mendelian Inheritance in Animals) database for horses. The gene discussed is SPRY4; the disease is hypogonadotropic hypogonadism.