Curcumin also induced cell cycle arrest via regulation of G0/G1 phase related factors including cyclin D1, cyclin-dependent kinase 2 (CDK-2), nuclear factor erythroid 2–related factor 2 (p21) and cyclin-dependent kinase inhibitor 1 (p27) and apoptosis in prostate cancer cells in vitro via down regulation of Notch signaling [80]. The gene discussed is CDKN1A; the disease is Familial prostate cancer.