In this sense, while aberrant activation of the developmental biological pathway Wnt/β-catenin was recognized to facilitate cancer stem cells and pulmonary fibrosis [61,62], TNF related apoptosis-inducing ligand (TRAIL) signaling cascade is emerging as a key mediator for malignant cell death as well as myofibroblast inhibition [63]. Here, TNFSF10 is linked to pulmonary fibrosis.