In women, the subjects with hypouricemia were younger and had lower levels of BMI, SBP, TP, ALT, TC, TG and LDL-C; lower proportion of medication for hypertension and dyslipidemia; higher levels of AST, HDL-C, FBG and eGFR; and higher proportion of medication for diabetes compared with those without hypouricemia. The gene discussed is GPT; the disease is metabolic syndrome.