By the use of advanced co-culture experiments in networks of two-dimensional silicon based microfluidics, it can be demonstrated that tumor organization, gap junction establishment, and intercellular compound transfer are anisotropic and non-random and reflect tumor progression signal spreading along spatial routes decorated with Cx43 containing structures like hemi-channels, gap junctions, connexons and tunneling nanotubes [28]. The gene discussed is GJA1; the disease is neoplasm.