NF-kB and STAT3 signaling pathways provoke tumor-stimulating reactions by the production of interleukin-6 (a well-known growth factor for myelomatous plasma cells), prostaglandin E2, matrix metalloproteinases, and RAGE stimulation in the microenvironment of a tumor [33,34,35]. This evidence concerns the gene NFKB1 and neoplasm.