Among these, saponin-containing products such as L. platyphylla, Red L. platyphylla, Aloe ferox, F. parviflora and P. emblica can be considered as potential candidate because they significantly recovered the stool excretion, intestinal motility, mucin secretion and histological structure in Lop-induced constipation model [11,13,14,15,18]. This evidence concerns the gene MUC5AC and Constipation.