Immunohistochemistry analysis of brain tissues in Azevedo et al. showed significantly higher expression of NLRP1, NLRP3, and AIM2, cytokines IL-1β, IL-18, IL-33, and caspase 1 in cases of ZIKV-induced microcephaly, highlighting IL-33 as one of the cytokines that exerts multiple actions in relation to necroptosis, pyroptosis, and activation of inflammasome [72]. Here, IL33 is linked to microcephaly.