Firstly, insulin resistance may have a direct effect on platelet function per se: MPV levels are higher in non‐obese, normoglycaemic people with insulin resistance than matched people without,14 with insulin resistance causing reduced platelet sensitivity to the anti‐aggregating effects of insulin.51, 52 In addition, there appears to be a relationship between inflammation, platelet activity and hepatic fibrosis. The gene discussed is INS; the disease is Insulin resistance.