For SNPs that regulated the co-expression of a given gene pair in trans, we found scenarios such as: (i) regulation of co-expression between genes annotated for the same GO terms (e.g., GLRX5 and RPS29 are both annotated for ‘metabolic processes’); (ii) regulation of co-expression between a TF and its known target gene (e.g., GATA2 and RAB24); and (iii) regulation of co-expression between disease-associated genes (e.g., SLC4A1 and TPM1 are associated with renal (Alper, 2003; Yenchitsomanus et al., 2005) and cardiovascular disease (England et al., 2017), respectively). This evidence concerns the gene GLRX5 and cardiovascular disorder.