This study planned to study two single–nucleotide variants of NKX2‐5 (rs2277923, rs28936670), two single–nucleotide variants of GATA4 (rs368418329, rs56166237) and one single–nucleotide variant TBX5 (rs6489957) in sporadic nonsyndromic CHD cases in Egyptian children with congenital cardiac septal deformity from Qalubeya. The gene discussed is GATA4; the disease is coronary artery disorder.