In addition to two polymorphisms of NKX2‐5 (rs2277923, rs28936670) variant in the cardiac septal defect, two variants in GATA4 (rs368418329, rs56166237) and one variant in TBX5 (rs6489957) seem to have a role in the pathogenesis of congenital heart disease. Here, TBX5 is linked to congenital heart disease.