NKX2-5 and hypothyroidism, congenital, nongoitrous, 2: Though alterations in NKX2‐5 are linked to an extensive variety of CHDs and thyroid dysgenesis, NKX2‐5 codes for a homeodomain–containing transcription factor with an important role in heart development, and mutations affecting this gene in individuals with congenital heart disease were reported (Dentice et al., 2006).