Hepatic toxicity varies according to the group of studied drugs, and, in theory, all medications used for IBD can lead to liver damage, including amino salicylates, steroids, methotrexate, thiopurines (azathioprine and its main active metabolite 6-mercaptopurine), and anti-TNF and anti-integrin immunobiological agents [6]. The gene discussed is TNF; the disease is inflammatory bowel disease.