FN1 and neoplasm: Integrin signaling regulates various angiogenetic functions [30]. ITGB3 shows coexpression with FN1 gene and two of the analyzed, downregulated genes which are IGF1 (Insulin-like growth factor 1) and RHOB (Ras homolog family member B). RHOB was postulated to act as a tumour suppressor and regulate apoptosis.