A therapeutic focus on the treatment of obesity includes development of ghrelin receptor antagonist which can cause multiple fold increase in appetite stimulation from the gut to the mind; ghrelin receptor inverse agonists would stop essential function of the ghrelin receptor, accordingly expanding the reaction to inhibitory signals to obstruct “between-suppers” food consumption (21). The gene discussed is GHSR; the disease is obesity due to melanocortin 4 receptor deficiency.