This was demonstrated by Frank et al., who targeted ABCB5 by way of a specific blocking monoclonal antibody to restore melanoma cells’ sensitivity to doxorubicin, and by Lancet group who demonstrated the sensitizing effect of zosuquidar, a P-gp inhibitor (Frank et al., 2005; Lancet et al., 2009). This evidence concerns the gene ABCB5 and melanoma.