Baskaran et al. (2017) reported that diet-induced obesity suppressed TRPV1 expression in adipose tissue. In addition, Kentish et al. (2015) demonstrated that ganglionic TRPV1 was inactivated in obese mice induced by high-fat diet. Moreover, TRPV1 deficiency exacerbates diet-induced obesity and insulin resistance (Lee et al., 2015). The gene discussed is TRPV1; the disease is obesity due to melanocortin 4 receptor deficiency.